The domain within your query sequence starts at position 287 and ends at position 420; the E-value for the 4pq8 domain shown below is 9e-8.

TWQALTTLDLSHNSICEIDESVKLIPKIEYLDLSHNGLRVVDNLQHLYNLVHLDLSYNKL
SSLEGVHTKLGNVKTLNLAGNFLESLSGLHKLYSLVNVDLRDNRIEQLDEVKSIGSLPCL
ERLTLLNNPLSIIP

This is a PDB domain - please see the PDBSUM entry of 4pq8 for further annotation